A total of 15 cases of osteonecrosis have been reported with oral alendronate, one with oral risedronate and one with ibandronate, taken for the treatment of osteoporosis or Paget's Disease (a disease of that makes bones weak and fragile).
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Although the absolute rate of death declined somewhat after the first year post-MI, the increased relative risk of death in NSAID users persisted over at least the next four years of follow-up.
There are times even now that Reub has moments of the jitters, usually in the AM (we give him his meds in the PM), but then he is fine.
I also started taking B12, D3 and iron this past March as my Dr.